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KMID : 0942820100090020125
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Journal of Korean Brain Tumor Society
2010 Volume.9 No. 2 p.125 ~ p.130
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Primary Central Nervous System Lymphoma of Brain Stem in an Immunocompetent Child
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Jeong Jae-Hyun
Kim Young-Zoon
Lee Eun-Hee
Lee In-Chang
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Abstract
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Although primary central nervous system lymphoma(PCNSL) can affect all age groups, it is rare in childhood; thus, its
incidence and prognosis in children have not been well defined and the best treatment strategy remains unclear. A nineyear old girl presented at our department with complaints of diplopia, dizziness, dysarthria, and right side hemiparesis Magnetic resonance imaging suggested a diffuse brain stem glioma with infiltration into the right cerebellar peduncle. The patient was surgically treated by craniotomy and frameless stereotactic-guided biopsy, and unexpectedly, the histopathology of the mass was consistent with diffuse large B cell lymphoma, and immunohistochemical staining revealed positivity for CD20 and CD79a. She was treated by radiosurgery at 12 Gy and subsequent adjuvant combination chemotherapy based on high dose methotrexate. Unfortunately, 10 months after diagnosis, she succumbed due to an acute hydrocephalic crisis.
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KEYWORD
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Central nervous system, Lymphoma, Brain Stem, Child
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